Continuous Manufacturing Of Nano-Assemblies For Mrna Based Therapies And Vaccines: From Batch To Industry Scale PhD 36 months PHD Programme By Loughborough University |TopUniversities
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Continuous Manufacturing Of Nano-Assemblies For Mrna Based Therapies And Vaccines: From Batch To Industry Scale PhD Continuous Manufacturing Of Nano-Assemblies For Mrna Based Therapies And Vaccines: From Batch To Industry Scale PhD

Location

Loughborough University, Loughborough, United Kingdom
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Subject Ranking

# 201-250QS Subject Rankings

Programme Duration

36 monthsProgramme duration

Tuitionfee

28,600 Tuition Fee/year

Application Deadline

10 Feb, 2025Application Deadline

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Programme overview

Main Subject

Engineering - Chemical

Degree

PhD

Study Level

PHD

Study Mode

On Campus

This PhD will focus on developing scalable manufacturing techniques for lipid nano-assemblies such as cubosomes, hexosomes and liposomes, tailored for mRNA encapsulation. The project will:
  • Investigate the role of micromixing in membrane systems to produce bespoke LNCs with precise characteristics.
  • Incorporate downstream processes such as dialysis/solvent exchange to improve nanoparticle quality.
  • Explore drying techniques (e.g., freeze-drying) to create stable powder formulations for extended storage.
  • Collaborate with researchers at Nottingham University to assess stability and mRNA transfection efficiency of the developed formulations.

Programme overview

Main Subject

Engineering - Chemical

Degree

PhD

Study Level

PHD

Study Mode

On Campus

This PhD will focus on developing scalable manufacturing techniques for lipid nano-assemblies such as cubosomes, hexosomes and liposomes, tailored for mRNA encapsulation. The project will:
  • Investigate the role of micromixing in membrane systems to produce bespoke LNCs with precise characteristics.
  • Incorporate downstream processes such as dialysis/solvent exchange to improve nanoparticle quality.
  • Explore drying techniques (e.g., freeze-drying) to create stable powder formulations for extended storage.
  • Collaborate with researchers at Nottingham University to assess stability and mRNA transfection efficiency of the developed formulations.

Admission Requirements

3.2+
6.5+
92+

10 Feb 2025
3 Years
Oct

International
28,600

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Climate Change Science and Management MSc arrows

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Pharmaceutical Science and Medicinal Chemistry MSc, PGDip, PGCert arrows

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Secondary Physical Education (11-18) PGCE arrows

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Big Splash Campaign School of Design and Creative Arts PhD arrows

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Cultural Currents in the Nineteenth and Twentieth Century: Continuities between 'Victorian' and 'Modernist' Literature PhD arrows

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Doctoral Research in Health Humanities PhD arrows

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Dynamic External Shading for Enhanced Visual and Thermal Comfort In Schools PhD arrows

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Women in Historical Fiction of the English Civil War Era Creative/Critical PhD arrows

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Demographic Changes and Economic Development PhD arrows

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3-Directional Frictional Mechanical Metamaterials (3DFMMs) PhD arrows

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A Multiscale Investigation of Dislocation-Grain Boundary Interactions in Next Generation Alloys PhD arrows

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Accessing New Chemistries: Tuning Reactivity of Chemical Processes Using Ionic Liquids arrows

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Active Noise Control of Automotive Tyres using Ultrasonic Parametric Arrays PhD arrows

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Adaptive Reconfigurable Intelligent Metasurfaces for 5G/6G Networks PhD arrows

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Advanced Additive Manufacturing For Radiofrequency System Design PhD arrows

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Advanced Antenna Arrays and Metasurfaces for 5G and Space PhD arrows

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Advanced Crystallisation Techniques for Sustainable Battery Recycling and Wastewater Treatment PhD arrows

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Advanced Modelling of Carbon Black Morphology in Methane Pyrolysis for CO2-Free Hydrogen Production PhD arrows

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Advancing AI-Driven Robotics for Injury Rehabilitation Transform the Future of Medical Robotics with Cutting-Edge Research PhD arrows

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Agricultural Robot Navigation in Complex Farm and Rugged Terrain Environments Using Deep Reinforcement Learning AI. PhD arrows

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An Integrated Approach for Damage Identification in Composite Materials PhD arrows

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Antimicrobial Gels for Biomedical Applications PhD arrows

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Application of Machine Learning for Job Scheduling in Computing Clouds PhD arrows

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Artificial Intelligence-Assisted Modular Metabolic Engineering for Netzero Commodity Manufacture PhD arrows

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Beyond Normal - Proteins in Alien Environments PhD arrows

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BioDyes - Expanding the Scope of Renewed and Renewable Textiles arrows

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Building Community Climate Resilience with Large Language Models and Remote Sensing PhD arrows

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CSC PhD Studentship in Exploring Advanced Materials for Wearable Sensors PhD arrows

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Catalytic And Adsorption Properties Of Polymeric Silver And Zinc Oxide Stabilized Nanocomposites Decorated On Reduced Graphene Oxide PhD arrows

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Cell Mechanics and Tumour Growth PhD arrows

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Cellular Automaton to Model Rapid Crystal Growth and Recrystallisation PhD arrows

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Cognitive Monitoring of Human Operators using Multi-modal Artificial Intelligence PhD arrows

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Continuous Manufacturing Of Nano-Assemblies For Mrna Based Therapies And Vaccines: From Batch To Industry Scale PhD arrows

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Countering Cyberattacks in Autonomous Vehicles PhD arrows

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Cryptographic Primitives for Symmetric Cryptography PhD arrows

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Crystallisation with 3D Printing Template and Hydrogel Templates PhD arrows

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Data and AI Powered Turbulence Modelling for Fusion Energy Cooling Flows PhD arrows

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Design and fabrication Custom Foot Orthotics PhD arrows

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Design of Programmable Mechanical Metamaterials PhD arrows

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Developing Diffusion Models for Electric Vehicle: Spatial-temporal analysis and Policy Evaluation PhD arrows

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Developing Natural Surfactants from Biomass for Industrial Applications PhD arrows

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Development of New Digital Technologies and Generative Artificial Intelligence Tools For The Next Generation Green-By-Design and Sustainable Pharmaceuticals PhD arrows

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Development of Robust Wall Modelling for Practical Aerodynamic High Fidelity Prediction Phd arrows

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Dynamic Deformation, Damage and Fracture Of Composites PhD arrows

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Energy Efficiency Optimisation of Electric Vehicles In Dynamic Driving Scenarios PhD arrows

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Engineering New Materials for Solid-State Cooling Phd arrows

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Enhancing Human-Robot Interaction: Leveraging Artificial Intelligence for Emotional Intelligence in Robotics PhD arrows

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Unveiling Molecular Mechanisms of the Beneficial Impact of Exercise on Cancer Metabolism PhD arrows

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Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD arrows

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Visual Data Mining on Proteins and Biomedicine Crystallisation PhD arrows

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Waste-derived Bioplastics for a Circular and Sustainable Food Packaging Economy PhD arrows

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Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD arrows

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Biomarkers of Aging PhD arrows

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Developing Prescription Guidelines for Passive Heat Therapy PhD arrows

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Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD arrows

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Energy Dissipation In Human Soft Tissue During Impacts PhD arrows

Energy Dissipation In Human Soft Tissue During Impacts PhD Energy Dissipation In Human Soft Tissue During Impacts PhD

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Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD arrows

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Bespoke Organometallic Compounds for Anticancer Studies PhD arrows

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Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD arrows

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Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD arrows

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Climate and Ecological Transitions Hub Studentship PhD arrows

Climate and Ecological Transitions Hub Studentship PhD Climate and Ecological Transitions Hub Studentship PhD

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Coherent State Methods in Spectral Asymptotics PhD arrows

Coherent State Methods in Spectral Asymptotics PhD Coherent State Methods in Spectral Asymptotics PhD

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Computational Modelling of Sustainable Alloys PhD arrows

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Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD arrows

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Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD arrows

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Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD arrows

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Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD arrows

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Digital Twins for Biofilm Management PhD arrows

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Dispersionless Integrable Systems In 2+1 Dimensions PhD arrows

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An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD arrows

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Climate Change, Work Design and Worker Wellbeing Phd arrows

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Communication and Social Change (CSC) Hub Studentship PhD arrows

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Enhancing Motivation in Sport and Exercise Contexts PhD arrows

Enhancing Motivation in Sport and Exercise Contexts PhD Enhancing Motivation in Sport and Exercise Contexts PhD

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Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD arrows

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