36 monthsProgramme duration
29,500 GBPTuition Fee/year
Feb, Jul, OctStarting Month
Programme overview
Main Subject
Medicine Related Studies
Degree
PhD
Study Level
PHD
Study Mode
On Campus
At present there are no effective drugs for pancreatic cancer treatment. (+)-Grandifloracin has been shown to be a promising anti-austerity agent, able to suppress several pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. However, it is extremely difficult to prepare in enantiomerically pure form and current methods only allow for side-chain diversification.
Our new technology (described in preliminary format in Angew. Chem. Int. Ed. 2022, e202205278) will enable, for the first time, significant diversification of the core structure, enabling rapid biological screening for new treatments. Importantly, this approach can deliver gram quantities of material in high enantiomeric purity.
Hence, we have devised three converging objectives for the project spanning chemistry and biology outlined below:
i) Synthesis of Grandifloracin analogues to explore chemical space.
ii) Establish a Structure-Activity-Relationship (SAR) map against PANC-1 cell lines.
iii) Identification of most active compounds from above and further synthesis and SAR screening.
The research project will be focused on Organic Chemistry in the Synthesis Research laboratories and will provide training in modern organic chemistry techniques, working alongside PhD students and post-doctoral members of the Buckley Group. The project student will also be exposed to and trained in the biological screening techniques required to assess the compounds of interest.
Our new technology (described in preliminary format in Angew. Chem. Int. Ed. 2022, e202205278) will enable, for the first time, significant diversification of the core structure, enabling rapid biological screening for new treatments. Importantly, this approach can deliver gram quantities of material in high enantiomeric purity.
Hence, we have devised three converging objectives for the project spanning chemistry and biology outlined below:
i) Synthesis of Grandifloracin analogues to explore chemical space.
ii) Establish a Structure-Activity-Relationship (SAR) map against PANC-1 cell lines.
iii) Identification of most active compounds from above and further synthesis and SAR screening.
The research project will be focused on Organic Chemistry in the Synthesis Research laboratories and will provide training in modern organic chemistry techniques, working alongside PhD students and post-doctoral members of the Buckley Group. The project student will also be exposed to and trained in the biological screening techniques required to assess the compounds of interest.
Programme overview
Main Subject
Medicine Related Studies
Degree
PhD
Study Level
PHD
Study Mode
On Campus
At present there are no effective drugs for pancreatic cancer treatment. (+)-Grandifloracin has been shown to be a promising anti-austerity agent, able to suppress several pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. However, it is extremely difficult to prepare in enantiomerically pure form and current methods only allow for side-chain diversification.
Our new technology (described in preliminary format in Angew. Chem. Int. Ed. 2022, e202205278) will enable, for the first time, significant diversification of the core structure, enabling rapid biological screening for new treatments. Importantly, this approach can deliver gram quantities of material in high enantiomeric purity.
Hence, we have devised three converging objectives for the project spanning chemistry and biology outlined below:
i) Synthesis of Grandifloracin analogues to explore chemical space.
ii) Establish a Structure-Activity-Relationship (SAR) map against PANC-1 cell lines.
iii) Identification of most active compounds from above and further synthesis and SAR screening.
The research project will be focused on Organic Chemistry in the Synthesis Research laboratories and will provide training in modern organic chemistry techniques, working alongside PhD students and post-doctoral members of the Buckley Group. The project student will also be exposed to and trained in the biological screening techniques required to assess the compounds of interest.
Our new technology (described in preliminary format in Angew. Chem. Int. Ed. 2022, e202205278) will enable, for the first time, significant diversification of the core structure, enabling rapid biological screening for new treatments. Importantly, this approach can deliver gram quantities of material in high enantiomeric purity.
Hence, we have devised three converging objectives for the project spanning chemistry and biology outlined below:
i) Synthesis of Grandifloracin analogues to explore chemical space.
ii) Establish a Structure-Activity-Relationship (SAR) map against PANC-1 cell lines.
iii) Identification of most active compounds from above and further synthesis and SAR screening.
The research project will be focused on Organic Chemistry in the Synthesis Research laboratories and will provide training in modern organic chemistry techniques, working alongside PhD students and post-doctoral members of the Buckley Group. The project student will also be exposed to and trained in the biological screening techniques required to assess the compounds of interest.
Admission Requirements
4.5+
180+
6.5+
120+
65+
3.3+
Students should have or expect to have at least a 2(i) Masters degree or equivalent.
3 Years
Feb
Jul
- Candidates are required to submit an essay(s) for acceptance
Tuition fees
Domestic
5,238 GBP
International
29,500 GBP
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