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Due to its asymptomatic nature, pancreatic cancer is highly resistant to current known chemotherapeutic agents at the point of diagnosis. This has led to a five-year survival rate of just 7% of patients in England (five-year survival trend for pancreatic cancer between 2000-2004 and 2010-2014). Combination therapies have become the first line therapies of choice (gemcitabine and erlotinib has been reported to show improved 1-year survival rates than the administration of gemcitabine alone). Even these provide only modest survival benefits (23% as opposed to 17%). It is therefore imperative that new therapeutic strategies are developed. Cancer is a complex disease but one of the significant challenges in the development of new therapies in this area is that pancreatic cells are hypovascular (deficient in blood vessels) in nature and cells can proliferate in nutrient deprived conditions. This feature is known as anti-austerity. So how can we exploit this? With this PhD project, we will look to gain a deeper understanding of the anti-austere nature of pancreatic cancer cells from a biological point of view to better inform the development of new and effective chemotherapeutic agents using synthetic, biological, and medicinal chemistry knowledge. The biological part of the project will be carried out using natural compounds such as (+)-Grandifloracin and its analogues. (+)-Grandifloracin, in particular has been reported to be more active against several pancreatic cancer cell lines than the clinically used pancreatic anti-cancer drug gemcitabine which have shown positive results in reducing the persistence of pancreatic cells. Using cutting edge catalysts developed at Loughborough, this will enable, for the first time, a systematic biological activity study on the core structure of (+)-Grandifloracin. In the laboratory (+)-Grandifloracin has been found to be very difficult to prepare in pure form and current routes only enable diversification of the outside structure, not the core. Importantly the core structure has been identified as being responsible for its significant biological activity. We have been able to successfully synthesise analogues (+)-Grandifloracin for which we have seen initial positive results. We will use the initial results to determine the relationship between the pharmacophore and the reduction in persistence of the cancer cells. Modification of this core would offer significant biological information in the drive to develop more aggressive and successful treatments for pancreatic cancer.
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Due to its asymptomatic nature, pancreatic cancer is highly resistant to current known chemotherapeutic agents at the point of diagnosis. This has led to a five-year survival rate of just 7% of patients in England (five-year survival trend for pancreatic cancer between 2000-2004 and 2010-2014). Combination therapies have become the first line therapies of choice (gemcitabine and erlotinib has been reported to show improved 1-year survival rates than the administration of gemcitabine alone). Even these provide only modest survival benefits (23% as opposed to 17%). It is therefore imperative that new therapeutic strategies are developed. Cancer is a complex disease but one of the significant challenges in the development of new therapies in this area is that pancreatic cells are hypovascular (deficient in blood vessels) in nature and cells can proliferate in nutrient deprived conditions. This feature is known as anti-austerity. So how can we exploit this? With this PhD project, we will look to gain a deeper understanding of the anti-austere nature of pancreatic cancer cells from a biological point of view to better inform the development of new and effective chemotherapeutic agents using synthetic, biological, and medicinal chemistry knowledge. The biological part of the project will be carried out using natural compounds such as (+)-Grandifloracin and its analogues. (+)-Grandifloracin, in particular has been reported to be more active against several pancreatic cancer cell lines than the clinically used pancreatic anti-cancer drug gemcitabine which have shown positive results in reducing the persistence of pancreatic cells. Using cutting edge catalysts developed at Loughborough, this will enable, for the first time, a systematic biological activity study on the core structure of (+)-Grandifloracin. In the laboratory (+)-Grandifloracin has been found to be very difficult to prepare in pure form and current routes only enable diversification of the outside structure, not the core. Importantly the core structure has been identified as being responsible for its significant biological activity. We have been able to successfully synthesise analogues (+)-Grandifloracin for which we have seen initial positive results. We will use the initial results to determine the relationship between the pharmacophore and the reduction in persistence of the cancer cells. Modification of this core would offer significant biological information in the drive to develop more aggressive and successful treatments for pancreatic cancer.
Admission Requirements
3.2+
6.5+
92+
01 Apr 2025
3 Years
Jan
Apr
Tuition fees
Domestic
4,786
International
27,500
Scholarships
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Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Loughborough University, Loughborough, United Kingdom
# 301-350QS Subject Rankings
36 monthsProgramme duration
27,500 Tuition Fee/year
01 Apr, 2025Application Deadline
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Cancer is a complex disease but one of the significant challenges in the development of new therapies in this area is that pancreatic cells are hypovascular (deficient in blood vessels) in nature and cells can proliferate in nutrient deprived conditions. This feature is known as anti-austerity. So how can we exploit this?
With this PhD project, we will look to gain a deeper understanding of the anti-austere nature of pancreatic cancer cells from a biological point of view to better inform the development of new and effective chemotherapeutic agents using synthetic, biological, and medicinal chemistry knowledge. The biological part of the project will be carried out using natural compounds such as (+)-Grandifloracin and its analogues. (+)-Grandifloracin, in particular has been reported to be more active against several pancreatic cancer cell lines than the clinically used pancreatic anti-cancer drug gemcitabine which have shown positive results in reducing the persistence of pancreatic cells.
Using cutting edge catalysts developed at Loughborough, this will enable, for the first time, a systematic biological activity study on the core structure of (+)-Grandifloracin. In the laboratory (+)-Grandifloracin has been found to be very difficult to prepare in pure form and current routes only enable diversification of the outside structure, not the core. Importantly the core structure has been identified as being responsible for its significant biological activity.
We have been able to successfully synthesise analogues (+)-Grandifloracin for which we have seen initial positive results. We will use the initial results to determine the relationship between the pharmacophore and the reduction in persistence of the cancer cells. Modification of this core would offer significant biological information in the drive to develop more aggressive and successful treatments for pancreatic cancer.
Programme overview
Main Subject
Chemistry
Degree
PhD
Study Level
PHD
Study Mode
On Campus
Cancer is a complex disease but one of the significant challenges in the development of new therapies in this area is that pancreatic cells are hypovascular (deficient in blood vessels) in nature and cells can proliferate in nutrient deprived conditions. This feature is known as anti-austerity. So how can we exploit this?
With this PhD project, we will look to gain a deeper understanding of the anti-austere nature of pancreatic cancer cells from a biological point of view to better inform the development of new and effective chemotherapeutic agents using synthetic, biological, and medicinal chemistry knowledge. The biological part of the project will be carried out using natural compounds such as (+)-Grandifloracin and its analogues. (+)-Grandifloracin, in particular has been reported to be more active against several pancreatic cancer cell lines than the clinically used pancreatic anti-cancer drug gemcitabine which have shown positive results in reducing the persistence of pancreatic cells.
Using cutting edge catalysts developed at Loughborough, this will enable, for the first time, a systematic biological activity study on the core structure of (+)-Grandifloracin. In the laboratory (+)-Grandifloracin has been found to be very difficult to prepare in pure form and current routes only enable diversification of the outside structure, not the core. Importantly the core structure has been identified as being responsible for its significant biological activity.
We have been able to successfully synthesise analogues (+)-Grandifloracin for which we have seen initial positive results. We will use the initial results to determine the relationship between the pharmacophore and the reduction in persistence of the cancer cells. Modification of this core would offer significant biological information in the drive to develop more aggressive and successful treatments for pancreatic cancer.
Admission Requirements
Tuition fees
Domestic
International
Scholarships
Selecting the right scholarship can be a daunting process. With countless options available, students often find themselves overwhelmed and confused. The decision can be especially stressful for those facing financial constraints or pursuing specific academic or career goals.
To help students navigate this challenging process, we recommend the following articles:
How to get a full scholarship
Looking for a fully-funded scholarship to see you into university? Find out how to boost your chances of getting one.
Scholarships to study abroad
Find scholarships to study abroad with our lists of international scholarships – categorized by country, by subject, and by type of student.
Scholarship Applications: Frequently Asked Questions
Get answers to all your questions about scholarship applications, including tips on how to find scholarships and chances of success.
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Accessing New Chemistries: Tuning Reactivity of Chemical Processes Using Ionic Liquids
Accessing New Chemistries: Tuning Reactivity of Chemical Processes Using Ionic Liquids
Active Noise Control of Automotive Tyres using Ultrasonic Parametric Arrays PhD
Active Noise Control of Automotive Tyres using Ultrasonic Parametric Arrays PhD
Adaptive Reconfigurable Intelligent Metasurfaces for 5G/6G Networks PhD
Adaptive Reconfigurable Intelligent Metasurfaces for 5G/6G Networks PhD
Advanced Additive Manufacturing For Radiofrequency System Design PhD
Advanced Additive Manufacturing For Radiofrequency System Design PhD
Advanced Antenna Arrays and Metasurfaces for 5G and Space PhD
Advanced Crystallisation Techniques for Sustainable Battery Recycling and Wastewater Treatment PhD
Advanced Modelling of Carbon Black Morphology in Methane Pyrolysis for CO2-Free Hydrogen Production PhD
Advancing AI-Driven Robotics for Injury Rehabilitation Transform the Future of Medical Robotics with Cutting-Edge Research PhD
Agricultural Robot Navigation in Complex Farm and Rugged Terrain Environments Using Deep Reinforcement Learning AI. PhD
An Integrated Approach for Damage Identification in Composite Materials PhD
Antimicrobial Gels for Biomedical Applications PhD
Application of Machine Learning for Job Scheduling in Computing Clouds PhD
Artificial Intelligence-Assisted Modular Metabolic Engineering for Netzero Commodity Manufacture PhD
Beyond Normal - Proteins in Alien Environments PhD
BioDyes - Expanding the Scope of Renewed and Renewable Textiles
Building Community Climate Resilience with Large Language Models and Remote Sensing PhD
CSC PhD Studentship in Exploring Advanced Materials for Wearable Sensors PhD
Catalytic And Adsorption Properties Of Polymeric Silver And Zinc Oxide Stabilized Nanocomposites Decorated On Reduced Graphene Oxide PhD
Cell Mechanics and Tumour Growth PhD
Cellular Automaton to Model Rapid Crystal Growth and Recrystallisation PhD
Cognitive Monitoring of Human Operators using Multi-modal Artificial Intelligence PhD
Continuous Manufacturing Of Nano-Assemblies For Mrna Based Therapies And Vaccines: From Batch To Industry Scale PhD
Countering Cyberattacks in Autonomous Vehicles PhD
Cryptographic Primitives for Symmetric Cryptography PhD
Crystallisation with 3D Printing Template and Hydrogel Templates PhD
Data and AI Powered Turbulence Modelling for Fusion Energy Cooling Flows PhD
Design and fabrication Custom Foot Orthotics PhD
Design of Programmable Mechanical Metamaterials PhD
Developing Diffusion Models for Electric Vehicle: Spatial-temporal analysis and Policy Evaluation PhD
Developing Natural Surfactants from Biomass for Industrial Applications PhD
Development of New Digital Technologies and Generative Artificial Intelligence Tools For The Next Generation Green-By-Design and Sustainable Pharmaceuticals PhD
Development of Robust Wall Modelling for Practical Aerodynamic High Fidelity Prediction Phd
Dynamic Deformation, Damage and Fracture Of Composites PhD
Energy Efficiency Optimisation of Electric Vehicles In Dynamic Driving Scenarios PhD
Engineering New Materials for Solid-State Cooling Phd
Enhancing Human-Robot Interaction: Leveraging Artificial Intelligence for Emotional Intelligence in Robotics PhD
Unveiling Molecular Mechanisms of the Beneficial Impact of Exercise on Cancer Metabolism PhD
Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
Visual Data Mining on Proteins and Biomedicine Crystallisation PhD
Waste-derived Bioplastics for a Circular and Sustainable Food Packaging Economy PhD
Life Sciences and Medicine (6)
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Biomarkers of Aging PhD
Biomarkers of Aging PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Natural Sciences (6)
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Climate and Ecological Transitions Hub Studentship PhD
Climate and Ecological Transitions Hub Studentship PhD
Coherent State Methods in Spectral Asymptotics PhD
Coherent State Methods in Spectral Asymptotics PhD
Computational Modelling of Sustainable Alloys PhD
Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD
Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD
Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD
Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD
Digital Twins for Biofilm Management PhD
Dispersionless Integrable Systems In 2+1 Dimensions PhD
Social Sciences and Management (6)
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
Climate Change, Work Design and Worker Wellbeing Phd
Climate Change, Work Design and Worker Wellbeing Phd
Communication and Social Change (CSC) Hub Studentship PhD
Communication and Social Change (CSC) Hub Studentship PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD