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This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events.
This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events.
Admission Requirements
3.2+
6.5+
92+
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a related subject. A relevant Master’s degree and/or experience will be an advantage. • A Master’s degree in Biology or related field. • Strong research skills, including experience with quantitative and/or qualitative methods. • Excellent written and verbal communication skills. Proficiency in English is essential. • Ability to work independently and collaboratively in a multidisciplinary team environment.
01 Apr 2025
3 Years
Oct
Tuition fees
Domestic
4,786
International
27,500
Scholarships
Selecting the right scholarship can be a daunting process. With countless options available, students often find themselves overwhelmed and confused. The decision can be especially stressful for those facing financial constraints or pursuing specific academic or career goals.
To help students navigate this challenging process, we recommend the following articles:
Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
Loughborough University, Loughborough, United Kingdom
# 100QS Subject Rankings
36 monthsProgram duration
27,500 Tuition Fee/year
01 Apr, 2025Application Deadline
Program overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events.
Program overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events.
Admission Requirements
• A Master’s degree in Biology or related field. • Strong research skills, including experience with quantitative and/or qualitative methods. • Excellent written and verbal communication skills. Proficiency in English is essential. • Ability to work independently and collaboratively in a multidisciplinary team environment.
Tuition fees
Domestic
International
Scholarships
Selecting the right scholarship can be a daunting process. With countless options available, students often find themselves overwhelmed and confused. The decision can be especially stressful for those facing financial constraints or pursuing specific academic or career goals.
To help students navigate this challenging process, we recommend the following articles:
How to get a full scholarship
Looking for a fully-funded scholarship to see you into university? Find out how to boost your chances of getting one.
Scholarships to study abroad
Find scholarships to study abroad with our lists of international scholarships – categorized by country, by subject, and by type of student.
Scholarship Applications: Frequently Asked Questions
Get answers to all your questions about scholarship applications, including tips on how to find scholarships and chances of success.
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Data and AI Powered Turbulence Modelling for Fusion Energy Cooling Flows PhD
Design and fabrication Custom Foot Orthotics PhD
Design of Programmable Mechanical Metamaterials PhD
Developing Diffusion Models for Electric Vehicle: Spatial-temporal analysis and Policy Evaluation PhD
Developing Natural Surfactants from Biomass for Industrial Applications PhD
Development of New Digital Technologies and Generative Artificial Intelligence Tools For The Next Generation Green-By-Design and Sustainable Pharmaceuticals PhD
Development of Robust Wall Modelling for Practical Aerodynamic High Fidelity Prediction Phd
Dynamic Deformation, Damage and Fracture Of Composites PhD
Energy Efficiency Optimisation of Electric Vehicles In Dynamic Driving Scenarios PhD
Engineering New Materials for Solid-State Cooling Phd
Enhancing Human-Robot Interaction: Leveraging Artificial Intelligence for Emotional Intelligence in Robotics PhD
Unveiling Molecular Mechanisms of the Beneficial Impact of Exercise on Cancer Metabolism PhD
Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
Visual Data Mining on Proteins and Biomedicine Crystallisation PhD
Waste-derived Bioplastics for a Circular and Sustainable Food Packaging Economy PhD
Life Sciences and Medicine (6)
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Adaptive and Predictive Computational Modelling of Biomaterials: A Digital Twin Framework for Next-Generation Personalised Healthcare PhD
Biomarkers of Aging PhD
Biomarkers of Aging PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Developing Prescription Guidelines for Passive Heat Therapy PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Does Socialised Real-Life Body Exposure Promote Body Image Positivity PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Energy Dissipation In Human Soft Tissue During Impacts PhD
Natural Sciences (6)
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Accelerated Screening and Synthesis of New Chemotherapeutic Agents for Pancreatic Cancer PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bespoke Organometallic Compounds for Anticancer Studies PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Bio-based Sustainable Materials for Autonomous Thermal Management in Wearables PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Biomimmetic Catalytic Asymmetric Synthesis of the Bisorbicillinoids and Related Products PhD
Climate and Ecological Transitions Hub Studentship PhD
Climate and Ecological Transitions Hub Studentship PhD
Coherent State Methods in Spectral Asymptotics PhD
Coherent State Methods in Spectral Asymptotics PhD
Computational Modelling of Sustainable Alloys PhD
Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD
Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD
Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD
Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD
Digital Twins for Biofilm Management PhD
Dispersionless Integrable Systems In 2+1 Dimensions PhD
Social Sciences and Management (6)
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
Climate Change, Work Design and Worker Wellbeing Phd
Climate Change, Work Design and Worker Wellbeing Phd
Communication and Social Change (CSC) Hub Studentship PhD
Communication and Social Change (CSC) Hub Studentship PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD