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Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
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Using the Metabolome to Study Aging and Geroprotectors in 3D Cell Models PhD
Loughborough University, Loughborough, United Kingdom
# 100QS Subject Rankings
36 monthsProgram duration
27,500 Tuition Fee/year
01 Apr, 2025Application Deadline
Program overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to...
Read more aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events. Read less
Program overview
Main Subject
Engineering - Mechanical
Degree
PhD
Study Level
PHD
Study Mode
On Campus
This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to...
Read more aging.
The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.
The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.
One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.
The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.
The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events. Read less
Admission Requirements
• A Master’s degree in Biology or related field. • Strong research skills, including experience with quantitative and/or qualitative methods. • Excellent written and verbal communication skills. Proficiency in English is essential. • Ability to work independently and collaboratively in a multidisciplinary team environment.
Tuition Fee
Domestic Students
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QS subject rankings
Subject: Engineering - Mechanical
Ranking criteria
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Climate and Ecological Transitions Hub Studentship PhD
Climate and Ecological Transitions Hub Studentship PhD
Coherent State Methods in Spectral Asymptotics PhD
Coherent State Methods in Spectral Asymptotics PhD
Computational Modelling of Sustainable Alloys PhD
Designing Classroom Tasks To Improve Students’ Learning Of Mathematics PhD
Developing Novel Antibiofilm Coatings for Sustainable Biofilm-Free Surfaces PhD
Development of Hybrid Microcomb Sources with Topologically Protected Dark Resonances for Simultaneous Classical and Quantum PhD
Development of Novel Bicyclopentanes (BCP) Bioisosteres From Bench Stable [1.1.1]-Propellane Precursors PhD
Digital Twins for Biofilm Management PhD
Dispersionless Integrable Systems In 2+1 Dimensions PhD
Social Sciences and Management (5)
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
An Evaluation of Erasmus+ Sport Projects and Their Impact on EU Sport Policy Development PhD
Climate Change, Work Design and Worker Wellbeing Phd
Climate Change, Work Design and Worker Wellbeing Phd
Communication and Social Change (CSC) Hub Studentship PhD
Communication and Social Change (CSC) Hub Studentship PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Enhancing Motivation in Sport and Exercise Contexts PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD
Out of School Youth Provision: An Analysis of Funding and Operational Resilience within the Sector PhD